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Chronic ischemic heart disease with silent ormanifested myocardial ischemia has been reported to cause1 out of 5 deaths/year, indicating that the prognosis of patientswith chronic stable angina is not entirely benign. Han X et al (2007) HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblasticleukemia and is a potential therapeutic target. It is not like a narrative review thatfocuses on constituent studies, but rather a systematic interpretation of the “themes, cat-egories, and relationships, arising from the data of the original studies” (Kent & Fineout-Overholt, 2008).
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